. 2013 Dec 24;111(1):361–366. doi: 10.1073/pnas.1309324111

Table 1.

Chromosomal bands and genome coordinates of the CNVs associated with schizophrenia and neurodevelopmental disorders

Locus	CNV region	Hg19 coordinates	N	Gene boundaries	Oh	Size (kb)	Associated disorders	Refs
1q21.1 del	Min	146,6-147,6	12	PRKAB2-NBPF24	4	1,050	Sz, ID, Epil, ASD	4, 5, 52, 53, 55
1q21.1 del	Max	146,5-148,7	20	PRKAB2- LOC645166	4	2,220	Sz, ID, Epil, ASD	4, 5, 52, 53, 55
2p16.3 del	Min	49,8-51,4	1	NRXN1	1	1,600	Sz, ID, Epil, ASD	3, 9, 52, 55, 56
2p16.3 del	Max	49,8-51,4	1	NRXN1	1	1,600	Sz, ID, Epil, ASD	3, 9, 52, 55, 56
3q29 del	Min	195,8-197,3	21	TFRC-BDH1	8	1,540	Sz, ID, ASD	55, 57, 58
3q29 del	Max	195,8-197,3	21	TFRC-BDH1	8	1,540	Sz, ID, ASD	55, 57, 58
7q11.23 dup	Min	72,4-74,2	37	NSUN5P2-GTF2I	9	1,770	Sz, ASD	59, 60
7q11.23 dup	Max	72,4-74,2	37	NSUN5P2-GTF2I	9	1,770	Sz, ASD	59, 60
7q36.1 del	Min	145,3-148,1	1	CNTNAP2	1	2,860	Sz, ID	56, 61
7q36.1 del	Max	145,3-148,1	1	CNTNAP2	1	2,860	Sz, ID	56, 61
7q36.3 dup	Min	158,8-159,0	1	VIPR2	1	140	Sz	54, 55
7q36.3 dup	Max	157,3-159,0	7	PTPRN2-VIPR2	3	1,649	Sz	54, 55
10q11.22-23 dup	Min	49,3-51,6	28	FRMPD2-TIMM23	6	2,300	DD	62
10q11.22-23 dup	Max	46,8-52,4	60	FAM35BP-SGMS1	15	5,600	DD	62
15q11.2 del	Min	22,7-23,2	5	TUBGCP5-WHAMMP3	2	500	Sz, ID, ASD	5, 52, 63
15q11.2 del	Max	22,7-23,2	5	TUBGCP5-WHAMMP3	2	500	Sz, ID, ASD	5, 52, 63
15q11-q13 dup	Min	23,8-28,6	14	MIR4508-HERC2	6	4,770	ASD	64
15q11-q13 dup	Max	22,4-29,1	34	OR4M2- LOC100289656	8	6,709	ASD	64
15q13.3 del	Min	32,3-32,5	1	CHRNA7	0	160	Sz, ID, Epil.	5, 6, 49, 52, 53, 55, 63, 65, 66
15q13.3 del	Max	29,2-33,0	28	APBA2-SCG5	6	3,793	Sz, ID, Epil.	5, 6, 49, 52, 53, 55, 63, 65, 66
16p13.11 dup/del	Min	15,5-16,3	9	MPV17L-ABCC6	4	850	Sz, ID, ASD, ADHD	46, 52, 63, 67
16p13.11 dup/del	Max	14,9-18,6	26	NOMO1-NOMO2	5	3,671	Sz, ID, ASD, ADHD	46, 52, 63, 67
16p11.2 dup	Min	29,7-30,1	27	SPN-GDPD3	9	452	Sz, ID, Epil., ASD, ADHD, BD	12, 55, 64, 68-70
16p11.2 dup	Max	29,6-30,2	32	SLC7A5P1-CORO1A	12	610	Sz, ID, Epil., ASD, ADHD, BD	12, 55, 64, 68-70
16p12.1 del	Min	21,9-22,4	8	UQCRC2-CDR2	1	440	DD, Epil.	63, 64, 71
16p12.1 del	Max	21,8-22,4	13	RRN3P1-CDR2	2	600	DD, Epil.	63, 64, 71
17q12 del	Min	34,8-36,1	15	ZNHIT3-HNF1B	5	1,290	Sz, HNPP, DD	72, 73
17q12 del	Max	34,4-36,1	24	CCL18-HNF1B	5	1,750	Sz, HNPP, DD	72, 73
22q11 del	Min	18,9-20,3	28	DGCR6-RTN4R	6	1,400	Sz, ID, ASD, ADHD, OCD, Mood	52, 53, 55, 64
22q11 del	Max	18,9-21,8	65	DGCR6- RIMBP3C	12	2,900	Sz, ID, ASD, ADHD, OCD, Mood	52, 53, 55, 64

Minimal CNV region is defined as the smallest size typically associated, which should approximate to the “critical” deletion or duplication sufficient to cause the disease phenotype and maximal CNV region as the largest extent of deletion or duplication typically seen at the locus. ADHD, attention deficit hyperactivity disorder; ASD, autism spectrum disorder; BD, bipolar disorder; DD, developmental delay; Epil, epilepsy; HNPP, hereditary neuropathic pressure palsies; ID, intellectual disability; Mood, mood disorders (including depression); N, number of genes; OCD, obsessive compulsive disorder; Oh, number of ohnologs; Sz, schizophrenia.