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Decreased mitochondrial zinc uptake in cancerous cell lines. RWPE-1, RWPE-2, and PC-3 prostate cell lines were incubated for 24 h in medium supplemented with (+) and without (−) 50 µM ZnCl2. RWPE-1 is the only cell line demonstrating a statistically significant (P < 0.001) increase in mitochondrial zinc uptake when incubated in zinc-enriched media.
