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(A) Diagram of the SuperBiHelix method, showing how the seven-helix TM bundle is partitioned into 12 independent helix pairs. The θ, ϕ, and η values for each helix in the pair are sampled with the other helices not present. (B) To efficiently determine a subset of conformations for each helix most likely to lead to the lowest energy bundles, we partition the seven-helix bundle into three QuadHelix bundles: TM1-TM2-TM3-TM7, TM2-TM3-TM4-TM5, and TM3-TM5-TM6-TM7.
