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Schematic representation of presynaptic mitochondria in the mammalian brain and their effect on synaptic remodeling. Donut-shaped mitochondria are negative neuromodulators associated with smaller active zones and fewer docked vesicles in the dorsolateral prefrontal cortex (dlPFC) of monkeys and correlated with poor delayed response memory. (Inset) Donut mitochondria form by curvature and self-fusion of preexisting mitochondrial tubules (10, 11).
