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. 2013 Dec 16;111(1):373–378. doi: 10.1073/pnas.1311987111

Fig. 7.

Fig. 7.

AOAH-deficient mice develop diminished Ag-specific Th17 immunity after oral immunization. (A and B) Supernatant IL-17 and IFN-γ levels from restimulated CD4+CD3+CD45+ T cells from the cLP (A) and mLN (B) of Aoah+/+ (dark bars) and Aoah−/− (white bars) mice orally immunized with OVA (250 μg) and/or LPS (50 μg) or naïve mice. (C and D) IL-6 mRNA (C) and protein (D) from CD103+CD11b+ALDH− cLP DCs harvested at 24 h after oral gavage of Aoah+/+ mice (dark bars) and Aoah−/− mice (white bars) with LPS. (E and F) Supernatant IL-17 levels from restimulated CD4+CD3+CD45+ T cells from the cLP (E) and mLN (F) of Aoah+/+ mice (dark bars) and Aoah−/− mice (white bars) orally immunized with OVA and LPS. Indicated mice received i.p. rmIL-6 with each round of oral immunization. Data are mean ± SD of triplicate samples.