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. 2013 Dec 16;111(1):167–172. doi: 10.1073/pnas.1314066111

Fig. 2.

Fig. 2.

Relationship between mRNA and protein accumulation profiles show that reduced protein amplitudes originate from long protein half-lives. (A) Percentage of rhythmic proteins (left scale) and fraction of rhythmic proteins (right scale) with nonrhythmic mRNA in function of FDR. (B) Protein half-lives (measured in NIH 3T3 cells) (19) are significantly longer in C1 and C2 (nonrhythmic proteins) compared with C3 and C4 (rhythmic proteins; P < 0.004, Wilcoxon rank sum test). C0 contains all protein half-lives measured in ref. 19. (C) Phase relationships between peak protein and mRNA accumulations (C3). Red lines show circular regression predicting a delay of 5.5 h. (D) Distribution of phase delay between peak protein and mRNA accumulations (C3).