Figure 5.

Activation of the NFkB pathway is compromised in thyroids from Spry1 knockout mice. (a) Immunostaining against p65 on frozen sections of thyroids of the indicated genotypes. (b) Steady-state levels of IκBα of thyroids from 3-month-old mice of the indicated genotypes. (c) Immunostaining against p65 on frozen sections of thyroids of the indicated genotypes, stimulated with LPS. (d) Left panel, nuclear translocation of p65 after stimulation with LPS. Right panel, IκBα levels on thyroids from mice of the indicated genotypes injected with saline or LPS