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. 2013 Nov 15;6:129–137. doi: 10.2147/JIR.S35901

Figure 2.

Figure 2

The JAK–STAT intracellular signaling pathway.

Notes: JAK is involved in the intracellular signal transduction pathways via STATs. JAK3 binds to the gamma chain, which is a common receptor subunit for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The JAK inhibitor, tofacitinib, mainly inhibiting JAK3 and JAK1, blocks the synthesis of proinflammatory cytokines (IFN-gamma, IL-6 and, to a lesser extent, IL-12 and IL-23).

Abbreviations: IL, interleukin; JAK, Janus kinase; STAT, signal transducers and activators of transcription; TNF, tumor necrosis factor; IFN, interferon.