Fig. 4.

EC-SOD does not ameliorate the exacerbated inflammatory response to infection observed in mice exposed to hyperoxia at birth. Adult female WT and EC-SOD Tg mice exposed to RA or O₂ at birth were intranasally infected with a sublethal dose of influenza A virus. Total leukocyte number (A), fold change in total leukocyte number (B), levels of monocyte chemoattractant protein (MCP)-1 (C), and fold change in MCP-1 present in bronchoalveolar lavage fluid (D) were determined on postinfection day 7 (n = 5–7 mice/group, *P < 0.05 compared with RA WT, #P < 0.05 compared with RA Tg).