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Excessive recruitment of leukocytes to lungs of infected mice exposed to neonatal hyperoxia is dependent upon MCP-1. Adult Mcp-1 WT and KO mice exposed to RA or O2 at birth were intranasally infected with a sublethal dose of influenza A virus. Total leukocyte number in bronchoalveolar lavage (BAL) fluid and postlavaged interstitium (Lung) were determined on postinfection days 3, 5, and 7 (n = 5–7 mice/group, *P < 0.05 compared with RA WT).
