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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Cell. 2013 Oct 31;155(4):948–962. doi: 10.1016/j.cell.2013.10.011

Fig. 7. Cumulative haploinsufficiency and triplosensitivity shape the cancer genome.

Fig. 7

Illustrative schematics of different concepts highlighted in the Discussion. A) The phenotypic continuum of cancer driver. B) The cancer gene island model for focal SCNAs. C) The cumulative gene dosage balance model for predicting the patterns of aneuploidy. D) Comparison of the predictions of Knudson’s Two-hit Hypothesis for TSGs compared the Haploinsufficiency Hypothesis presented in this study.