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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2013 Jan 29;6(2):171–183. doi: 10.1161/CIRCGENETICS.112.964619

Figure 1.

Figure 1

Major fatty acids in the de novo lipogenesis pathway. Palmitic acid (16:0), stearic acid (18:0), palmitoleic acid (16:1n-7), and oleic acid (18:1n-9) are the major saturated and mono-unsaturated fatty acids that are obtained via de novo lipogenesis (DNL) or the diet, and investigated in this study (the metabolic steps which link the fatty acids are in italics, and the key enzyme involved in these processes labeled in brackets). In the initial steps of DNL, fatty acid synthase (FAS) catalyze the polymerization of malonyl-CoA to form 16:0 as the major initial product. 16:0 can be elongated to 18:0, and cellular studies suggested elongase-6 (Elov6) is the enzyme primarily responsible for this conversion 29. Both 16:0 and 18:0 are substrates for stearoyl-CoA desaturase (SCD) to give rise to 16:1n-7 and 18:1n-9, respectively 2.