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Oxidative stress and nitroso-redox evaluation. Aortae were removed from 6-mo-old mice (n > 5 per group) and analyzed for: A: NADPH oxidase activity; B: gp91 phox mRNA levels (by qRT-PCR); E: Niemann-Pick disease, type c1 (NPC-1) mRNA levels; and F: GSH content. C and D: plasma lipid peroxidation levels by thiobarbituric acid-reactive substances (TBARS; n ≥ 8 each age group) and 8-isoprostane. Values are presented as means ± SE. *P < 0.05 and †P < 0.01 vs. Cc1+/+.
