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Effects of CaMKIIδC hyperactivity (or mutation 1795insD) on Na current (INa) gating. SSI and activation voltage dependence (A), entry of Na channels into intermediate inactivation (B), recovery from inactivation (C), and late INa (INa,L; D) are assessed with the voltage clamp protocols shown in insets in control (solid lines) and CaMKIIδC overexpression/1795insD mutation (dashed lines).
