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. 2013 May 22;305(4):F568–F573. doi: 10.1152/ajprenal.00613.2012

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Fig. 8. — ET-1 receptor inhibitors block ET-1 regulation of Na reabsorption, J_Na. ET-1 significantly inhibited J_Na (basal control 72.6 ± 8.6 vs. ET-1 control 26.8 ± 7.2, P < 0.05, n = 6). Benzamil significantly inhibited J_Na in the absence of ET-1 (basal control 72.6 ± 8.6 vs. benzamil 43.8 ± 8.7, P < 0.05, n = 6) and in the presence of ET-1 plus the ET_A receptor inhibitor BQ-123 (ET-1 + BQ-123 control 79.8 ± 8.9 vs. benzamil 52.8 ± 8.3, P < 0.05, n = 6). Benzamil did not inhibit J_Na in the presence of ET-1 plus the ET_B receptor inhibitor BQ-788 (ET-1 + BQ-788 control 79.2 ± 19.4 vs. benzamil 75.9 ± 13.4, P = NS). *P < 0.05, compared with control of the same condition. **P < 0.05, compared with basal control.