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. 2011 Oct 10;32(11):1327–1336. doi: 10.1038/aps.2011.106

Figure 6.

Figure 6

The presence of the Aβ peptide in the brain of Slit2 mice. (A and D) Detection of Aβ 40 in Slit2 and C57 mouse brains. IHC of Slit2 mouse brain slides (A) stained with Aβ 40 antibody. No staining was observed in slides prepared from C57 mouse brains (D). (B, C and E, F) Detection of Aβ 42 in Slit2 and C67 mouse brains. IHC of Slit2 mouse brain slides (B, C) stained with Aβ 42 antibody. No staining was observed in slides prepared from C57 mouse brains (E, F). (G, H, I and J, K) Blood-borne FITC-labeled Aβ42 crosses the blood-brain barrier, enters into the brain tissue and binds selectively to neurons in Slit2 mice (G). Within 1 h post-injection, FITC-labeled Aβ42 leaked from local vessels and bound to the surfaces of neurons (H, I). At 24 and 48 h post-injection, neurons bound with FITC-labeled Aβ42 were abundant in the indicated brain regions. NO FITC-labeled Aβ42 bound to neurons in C57 mice (J, K).