Table 1.
Top 25 altered genes in liver of aflatoxin B1-exposed, H hepaticus-infected female mice with tumours vs uninfected controls
| Upregulated | FC | Gnd | Downregulated | FC | Gnd |
|---|---|---|---|---|---|
| Ubiquitin D | 26.08 | F | ATPase, H+ transporting, lysosomal V0 subunit A1 | −5.93 | |
| Vacuolar protein sorting 13A (yeast) | 17.03 | Protein C | −5.85 | ||
| RIKEN cDNA 4732454E20 gene | 12.66 | Phytoceramidase, alkaline | −4.58 | ||
| UDP-glucose:ceramide glucosyltransferase | 12.25 | IQ motif and WD repeats 1 | −4.46 | ||
| Serum amyloid A 3 | 11.88 | F | Sulfotransferase family 5A, member 1 | −4.00 | M |
| Neuregulin 3 | 9.90 | RIKEN cDNA A930011E06 gene | −3.98 | ||
| H19 fetal liver mRNA | 8.30 | Nuclear factor, erythroid derived 2 | −3.77 | F | |
| Similar to Ig heavy chain V region 23 | 7.69 | F | Solute carrier family 1, member 2 | −3.65 | |
| RIKEN cDNA 3830431G21 gene | 6.84 | D site albumin promoter-binding protein | −3.41 | F | |
| Chemokine (C-X-C motif) ligand 9 | 6.69 | F | Excision rodent repair deficiency, complementation group 4 | −3.27 | |
| Alpha-fetoprotein | 6.30 | M | ATP citrate lyase | −3.23 | F |
| RIKEN cDNA 4930408O21 gene | 6.13 | F | RIKEN cDNA 4833422M21 gene | −3.05 | M |
| CDK inhibitor 1A (P21) | 5.72 | RIKEN cDNA 4933426I21 gene | −2.97 | ||
| PPAR gamma | 5.60 | Serine (or cysteine) peptidase inhibitor, clade B, member 6c | −2.96 | ||
| Killer cell lectin-like receptor B, 1D | 5.35 | Storkhead box 2 | −2.95 | ||
| Adenylate cyclase 1 | 5.29 | d-Amino acid oxidase 1 | −2.94 | ||
| Interferon-activated gene 203 | 5.06 | Major urinary protein 1 | −2.90 | M | |
| Carboxylesterase 3 | 5.04 | Hypothetical LOC574418 | −2.88 | ||
| RIKEN cDNA 3110047M12 gene | 4.96 | F | Somatostatin receptor 3 | −2.85 | |
| RIKEN cDNA 2610305J24 gene | 4.78 | F | Interleukin-1 receptor-associated kinase 1-binding protein 1 | −2.76 | |
| Vang-like 2 (van gogh, Drosophila) | 4.69 | AF4/FMR2 family, member 2 | −2.76 | ||
| Striatin, calmodulin binding protein 3 | 4.68 | Inhibitor of growth family, member 5 | −2.76 | ||
| Scm-like with four mbt domains 1 | 4.68 | Tripartite motif protein 27 | −2.68 | M | |
| cDNA sequence AB182283 | 4.51 | Neurofibromatosis 2 | −2.66 | ||
| Maternal embryonic message 1 | 4.47 | M | Solute carrier family 25, member 19 | −2.61 |
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CDK, cyclin-dependent kinase; FC, fold change; Gnd, gender-dimorphic transcript (F, feminine; or M, or masculine); Ig, immunoglobulin; PPAR, peroxisome proliferatoractivated receptor.