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Airway hyperresponsiveness to inhaled methacholine was measured and expressed as PC200, the concentration of methacholine required to increase the baseline Penh by 200%. The airway hyperresponsiveness was increased in IPOA-2, IPOA-7, and IPO-7 and there was no difference of PC200 among them (p> 0.05). Each bar indicates the mean (SEM) value. *p< 0.05, **p< 0.001
