Table 2.

Coagulation factor analysis of spray dried plasma^*

			Spray dried plasma
	Standard FFP
	(control)		1.5% glycine†			Deionized water‡
Parameter	mean	± SD	mean	± SD	P compared to control	mean	± SD	P compared to 1.5% glycine
Fibrinogen (Factor I) (mg/dL)	372.8	154.7	320.8	99.0	NS††	267.3	84.2	0.03
Factor V (%)	70.2	20.0	55.7	19.7	NS	17.5	8.1	0.03
Factor VII (%)	72.8	23.7	62.8	27.1	NS	58.3	18.4	NS
Factor VIII (%)	108.0	33.0	62.7	19.6	0.03	36.8	14.0	0.03
Factor IX (%)	101.0	23.0	91.2	28.5	NS	70.3	19.4	0.03
Protein C (%)	81.2	11.9	75.5	14.8	NS	74.5	9.3	0.03
Protein S (%)	102.7	17.1	73.5	25.2	NS	77.7	17.6	0.03
vWF antigen (IU/dL)	112.3	52.2	84.8	30.1	0.03	97.8	39.2	NS
vWF activity (IU/dL)	110.7	34.4	82.7	35.6	0.03	58.0	25.9	0.03
ADAMTS-13 (%)	108.3	23.5	98.3	20.2	NS	89.3	8.1	NS

^*Single donor products were analyzed (n = 6; sign test).

^†The lowest recovery rates were 58% for factor VIII, 72% for protein S and 75% for both vWF assays compared to control. The recovery rates for the remaining parameters ranged from 79% to 93%.

^‡The lowest recovery rates were 25% for factor V and factor VIII compared to FFP controls. The recovery rates for the remaining parameters ranged from 52% to 92%.

^††NS – not statistically significant (P ≥ 0.05)