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. Author manuscript; available in PMC: 2014 Jan 14.
Published in final edited form as: Nature. 2013 Oct 16;503(7474):136–140. doi: 10.1038/nature12605

Figure 4. Reduction in α-DG LARGE-glycan chain length during myogenesis results in NMJ defects.

Figure 4

a, Hind-paw clasping phenotype during tail suspension in LargeKD mice, 21 days after injury to the tibialis anterior and gastrocnemius muscles. b, Representative confocal images of AChR-labelled NMJs. c, Scoring of NMJ defects by blinded observers (scoring criteria in Methods, interaction P=0.011 for fragmentation). d, e, Average AChR aggregation after ligand addition to control (white) or LargeKD (black) DD4 myotubes (interaction P<0.001 for total number and P=0.007 for size; error bars indicate s.e.m.; ×20 magnification images, n=16 per group). Post-hoc comparisons for c–e *P<0.05, **P<0.0001.