Figure 3. Visualizing efficacy of immunity.

in A) intact mice for different starting inoculum sizes (y axis labels); and B) intact mice and intact mice treated with IL-10R, which up-regulates innate immunity (y axis labels to the right). Surfaces show smoothed proportion of infected cells killed, p_t, against time in days (x axis) with mice ranked via their early densities within each category (rows, y axis); dashed thick line indicates the timing of the first major peak of infection; and for A) the crosses indicate secondary peaks, generally following dips in immune efficacy. In A) higher early densities experience an earlier increase in mortality of infected cells but this effect decays, then increases, finally dipping significantly around the 35^th day associated with a resurgence of parasites. In B) mice treated with IL-10R experience an earlier peak in immune efficacy. However, treated mice generally died by day 9.