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Figure 1. NKG2D-mediated fratricidal regulation of natural killer cells. (A) Natural killer (NK) cells recognize NKG2D ligand (NKG2DL)-expressing malignant cells and attack them with cytotoxic granules containing perforin. (B) NKG2D-NKG2DL interactions result in the downregulation of NKG2D as well as in the rapid acquisition of NKG2DL by NK cells. (C) NKG2DL-dressed NK cells are eliminated by fratricide in an NKG2D- and perforin-dependent manner.
