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. 1971 Jun;68(6):1249–1250. doi: 10.1073/pnas.68.6.1249

Acetoxycycloheximide and Transient Amnesia in the Rat

Roger G Serota 1,2,3
PMCID: PMC389164  PMID: 5288371

Abstract

Rats were trained during the severe inhibition of protein synthesis that follows intracerebral injection of acetoxycycloheximide. Amnesia was consistently observed 24 hours after training, but memory spontaneously returned within 6 days. There was, consequently, no evidence of interference by acetoxycycloheximide with the consolidation phase of memory, but rather a transient deficit in the retrieval phase. It is suggested that this deficit may be due to a deficiency in neurotransmitters.

Keywords: valine incorporation, hippocampus, cortex, short term, long term

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agranoff B. W., Davis R. E., Brink J. J. Chemical studies on memory fixation in goldfish. Brain Res. 1966 Mar-Apr;1(3):303–309. doi: 10.1016/0006-8993(66)90095-3. [DOI] [PubMed] [Google Scholar]
  2. Barondes S. H., Cohen H. D. Delayed and sustained effect of acetoxycycloheximide on memory in mice. Proc Natl Acad Sci U S A. 1967 Jul;58(1):157–164. doi: 10.1073/pnas.58.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FLEXNER L. B., FLEXNER J. B., ROBERTS R. B., DELAHABA G. LOSS OF RECENT MEMORY IN MICE AS RELATED TO REGIONAL INHIBITION OF CEREBRAL PROTEIN SYNTHESIS. Proc Natl Acad Sci U S A. 1964 Nov;52:1165–1169. doi: 10.1073/pnas.52.5.1165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Flexner L. B., Flexner J. B., Roberts R. B. Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning. Proc Natl Acad Sci U S A. 1966 Aug;56(2):730–735. doi: 10.1073/pnas.56.2.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. Quartermain D., McEwen B. S., Azmitia E. C., Jr Amnesia produced by electroconvulsive shock or cycloheximide: conditions for recovery. Science. 1970 Aug 14;169(3946):683–686. doi: 10.1126/science.169.3946.683. [DOI] [PubMed] [Google Scholar]
  7. Roberts R. B., Flexner J. B., Flexner L. B. Some evidence for the involvement of adrenergic sites in the memory trace. Proc Natl Acad Sci U S A. 1970 Jun;66(2):310–313. doi: 10.1073/pnas.66.2.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Schoenfeld R. I., Seiden L. S. Effect of alpha-methyltyrosine on operant behavior and brain catecholamine levels. J Pharmacol Exp Ther. 1969 Jun;167(2):319–327. [PubMed] [Google Scholar]
  9. Seiden L. S., Peterson D. D. Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-dopa: correlation of behavioral and biochemical differences in two strains of mice. J Pharmacol Exp Ther. 1968 Feb;159(2):422–428. [PubMed] [Google Scholar]

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