. 2014 Jan 14;9(1):e83865. doi: 10.1371/journal.pone.0083865

Table 2. Rat toxicokinetics summary.

		Total Antibody			ADC
Antibody	Dose (mg/kg)	T_{1/2 (days)}	C_{max (µg/ml)}	AUC _{last(day*µg/ml)}	T_{1/2 (days)}	C_{max (µg/ml)}	AUC _{last(day*µg/ml)}
Anti-Her2 position 1-ADC	30	9.12±2.19	1003±41.9	2418±168	7.89±1.32	1056±55.7	2554±178
Anti-Her2 position 1-ADC	60	4.36±0.495	2244±130	4978±865	4.94±0.812	2361±189	4959±604
Anti-Her2 position 1-ADC	90	2.40±0.871	3104±188	6153±838	2.31±0.734	3469±417	6214±974
Anti-Her2 Cys-ADC	30	7.31±2.03	781±19.1	1801±270	6.35±1.47	757±69.2	1581±228
Anti-Her2 Cys-ADC	45	4.91±0.871	1271±124	2726±182	4.60±0.926	1269±79.3	2429±167
Anti-Her2 Cys-ADC	90	3.13±0.852	1740±214	2938±314	3.04±0.885	1827±152	2696±300

Serum from rats dosed with 30, 45 or 60 mg/kg of anti-Her2 Cys-ADC or 30, 60 or 90 mg/kg of anti-Her2 position 1-ADC were collected and the total amount of antibody and ADC was measured via ELISA. The toxicokinetic parameters were calculated.