Table 3. Hematology summary.

Parameter	Control	Anti-Her2 position 1-ADC	Anti-Her2 position 1-ADC	Anti-Her2 position 1-ADC	Anti-Her2 Cys-ADC	Anti-Her2 Cys-ADC	Anti-Her2 Cys-ADC
		30 mg/kg	60 mg/kg	90 mg/kg	30 mg/kg	45 mg/kg	60 mg/kg
Hemoglobin	14.7±0.2	13.4±0.5	11.9±1.0	11.9±1.0	12.4±0.7	12.6±0.5	10.8±0.9
RDW	11.9±0.3	14.4±0.5	15.6±1.2	17.5±0.5	15.0±0.6	18.6±2.9	21.4±3.3
Reticulocyte Count	2.23±0.24	4.14±1.02	4.18±1.16	6.57±1.21	4.30±0.86	7.42±2.39	7.63±1.22
Platelet Count	1158±190	1433±246	1239±514	879±532	1290±348	960±513	627±246
WBC	4.7±1.8	8.8±2.5	16.4±12.6	26.1±9.0	10.7±1.5	18.4±6.8	30.6±14.5
Neutrophil Count	688±304	2260±585	6674±4749	11799±4439	4122±817	8137±4616	13023±4330
Lymphocyte Count	3794±1237	5947±1951	8493±7481	12269±4713	5584±873	8264±2287	13719±8196
Monocyte Count	99±49	322±174	643±411	1356±797	425±155	1045±861	2991±19923

Comparison of selected hematology measurements between cysteine and site specifically conjugated Her2 ADCs. Hematology measurements were evaluated post single dose, i.v. administration of 30, 45 or 60 mg/kg of the anti-Her2 Cys or 30, 60 or 90 mg/kg of the anti-Her2 position 1-ADC. Data represent Mean ± SD.