Table 4. Rat serum chemistry summary.

Parameter	Control	Anti-Her2 position 1-ADC	Anti-Her2 position 1- ADC	Anti-Her2 position 1- ADC	Anti-Her2 Cys-ADC	Anti-Her2 Cys-ADC	Anti-Her2 Cys-ADC
		30 mg/kg	60 mg/kg	90 mg/kg	30 mg/kg	45 mg/kg	60 mg/kg
ALT	33±3	51±8	122±88	112±27	178±98	180±124	345±365
AST	108±28	223±38	697±770	619±294	848±351	732±381	2419±2853
Alkaline phosphatase	150±28	196±53	612±680	573±318	329±72	541±183	898±412
GGT	2±0	3±1	26±41	36±27	7±6	19±14	50±29
BUN	15±1	21±2	22±13	19±3	22±3	21±8	42±15
Globulin	2.3±0.1	3.0±0.2	3.6±0.5	3.9±0.4	3.8±0.4	3.6±0.2	3.2±0.4
Albumin	3.1±0.1	3.0±0.1	2.7±0.2	2.6±0.2	2.8±0.3	2.3±0.2	2.0±0.3
A/G	1.3±0.1	1.0±0.1	0.8±0.2	0.7±0.1	0.8±0.1	0.7±0.1	0.6±0.1
Triglycerides	53±14	52±14	92±41	216±69	61±16	190±186	195±57

Comparison of selected serum chemistry parameters (Day 15) between cysteine and site specifically conjugated Her2 ADCs. A panel of serum markers was evaluated post single dose, i.v. administration of 30 or 60 mg/kg or 90 mg/kg of the anti-Her2 Cys or 30, 45 or 60 mg/kg anti-Her2 position 1-ADC.