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. Author manuscript; available in PMC: 2014 Jan 14.
Published in final edited form as: Cancer Gene Ther. 2012 May 4;19(6):393–401. doi: 10.1038/cgt.2012.12

Figure 1.

Figure 1

Recombinant S. Typhimurium distribution in C57/BL6 tumor-bearing mice. (a) By using GFP expression as a marker, the bacteria distribution in different organ tissues at specified times after inoculation of bacteria (*P<0.01). (b) The GFP expression was observed in tumor and liver tissues by fluorescence microscope. (c) Electron microscopic analyses of S. Typhimurium infecting H22 tumors. Left panel: bacteria in the intercellular substance of tumor tissues, middle panel: bacteria in the cellular nucleus that was being autolyzed, right panel: bacteria in the tumor-associated macrophage. The arrows indicate the bacteria.