Figure 2. Schematic representation of promoter CpG island hypermethylation in cancer. Filled and unfilled lollypops represent methylated and unmethylated CpGs, respectively. HAT, histone acetyltransferase; Pol II, DNA polymerase II; DNMT, DNA methyl transferase; HDAC, histone deacetylase; PcG, polycomb group proteins.