Table 2. Differentially methylated autosomal genes that co-varied in brain and blood DNA from PD patients.
| A. Genes with increased methylation in PD | ||
|---|---|---|
| GENE NAME | Delta Beta Brain | Delta Beta Blood |
| KCTD540 | 0.429 | 0.465 |
| VAV237,38,40 | 0.374 | 0.426 |
| MOG36,38,39 | 0.357 | 0.336 |
| TRIM1038 | 0.352 | 0.397 |
| †HLA-DQA138,49 | 0.325 | 0.290 |
| ARHGEF1037,38,40 | 0.319 | 0.356 |
| †GFPT238,42,50 | 0.291 | 0.253 |
| *HLA-DRB536 | 0.282 | 0.255 |
| TMEM937,38 | 0.274 | 0.249 |
| MRI140 | 0.258 | 0.284 |
| †MAPT 37, 38, 44, 49–52 | 0.247 | 0.295 |
| HLA-DRB6 | 0.240 | 0.279 |
| LASS3 | 0.230 | 0.243 |
| GSTTP238,41,53 | 0.222 | 0.207 |
| GSTTP138,42,44 | 0.218 | 0.258 |
| B. Genes with decreased methylation in PD | ||
|---|---|---|
| Gene name | Delta beta brain | Delta beta blood |
| DNAJA3 | -0.445 | -0.511 |
| *JAKMIP337,40 | -0.403 | -0.362 |
| FRK36,47 | -0.386 | -0.341 |
| LRRC27 | -0.382 | -0.406 |
| DMBX1 | -0.370 | -0.354 |
| LGALS7 | -0.368 | -0.380 |
| FOXK1 | -0.317 | -0.340 |
| APBA137,38 | -0.312 | -0.283 |
| MAGI236–38,42 | -0.306 | -0.228 |
| SLC25A2438 | -0.253 | -0.241 |
| GSTT138,42,44 | -0.239 | -0.239 |
| *MYOM244 | -0.228 | -0.201 |
| *†MIR88651 | -0.214 | -0.242 |
| TUBA3E | -0.210 | -0.210 |
| TMCO338,40 | -0.207 | -0.203 |
Selected genes differentially methylated in brain and blood genomes (top 15 per group). *Loci with more than 2 probes with differential methylation on the array (Delta β represents average value from all detected probes). †Expression deregulated and/or linked to GWAS in PD.