Table 2. Linear regression of IGF2/H19 methylation jointly on maternal and supply line factors over all five cell types combined.

Factor	All Assays Combined		H19 promoter DMR		IGF2/H19 ICR		IGF2 DMR0		IGF2 DMR2
	Coeff	p-val	Coeff	p-val	Coeff	p-val	Coeff	p-val	Coeff	p-val
Had folate	0.50%	0.44	-1.70%*	0.024*	0.40%	0.69	0.90%	0.46	2.90%*	0.035*
Vitamin B12 (z-score)	-0.23%	0.24	-0.97%*	0.002*	-0.23%	0.54	0.23%	0.55	0.27%	0.63
Homocysteine (z-score)	0.27%	0.29	0.10%	0.75	0.40%	0.29	0.37%	0.30	0.17%	0.72
Macronutrients (z-score)	0.37%	0.17	0.80%*	0.049*	0.20%	0.50	0.43%	0.27	0.10%	0.77
Had alcohol	0.50%	0.27	0.00%	0.98	-0.70%	0.18	1.30%	0.14	1.90%	0.062
Smoked	0.90%	0.059	2.10%*	0.005*	1.20%*	0.043*	0.30%	0.74	-0.10%	0.90
Stress (z-score)	-0.10%	0.68	0.00%	0.98	-0.27%	0.42	0.30%	0.58	0.17%	0.65
Gestational diabetes	-1.30%*	0.012*	-1.50%	0.14	-0.80%	0.44	-1.50%	0.14	-1.60%	0.17
Central cord insertion (MC)	3.00%*	< 0.001*	3.20%*	0.046*	2.40%*	0.005*	2.70%*	0.001*	4.30%*	0.002*
Central cord insertion (DC)	-0.30%	0.47	0.80%	0.28	1.80%*	0.001*	-1.80%*	0.045*	0.00%	0.98
Placenta Weight	0.53%*	0.044*	0.53%	0.18	0.87%*	0.010*	0.30%	0.57	0.27%	0.60

Coefficients measure difference in absolute percentage methylation. The “All Assays Combined” columns display the data from all assays and tissues are combined, the rest of the table displays the data resulting from associations analyzed separately for each assay. Coefficient for placenta weight, vitamin B12, homocysteine, macronutrients and stress score represents difference in mean methylation for a 1 standard deviation increase in the corresponding factor. Central cord insertion indicates central vs. non-central (peripheral and velamentous) insertion. *Coefficients with P-values less than 0.05. Confidence intervals are shown in Table S3.