Table 1. Bronchoalveolar lavage fluid antibody responses to P. aeruginosa antigens.
| Ig Isotype (ng/mL) | Antigen | Group 1 CF Chronic LRTI (+) |
Group 2 CF LRTI (+) to (-) |
Group 3 CF URT (+) LRTI (-) |
Group 4 [b] CF URT (-) LRTI (-) |
Group 5 [b] Non-CF controls |
|---|---|---|---|---|---|---|
| IgG | WKC extract | 47.0 [30.2 - 63.9] |
27.5 [15.4 - 39.6] |
42.0 [26.7 – 57.6] |
31.7 | 30.8 |
| OprF | 40.4 [33.9 – 47.0] |
23.1 [8.3 - 37.8] |
42.8 [24.2 – 61.5] |
31.4 | 30.3 | |
| KatA | 32.1 [20.4 – 43.8] |
22.7 [8.3 – 37.1] |
35.7 [28.5 – 42.9] |
29.2 | 28.2 | |
| OprH | 20.9 [2.3 – 39.5] |
10.0 [a] |
22.9 [8.3 – 37.6] |
31.0 | 29.8 | |
| IgA | WKC extract | 1597.0 [277.6 – 2041.7] |
200.0 [1.1 – 398.9] |
437.8 [0 – 1127.8] |
82.4 | ND |
| OprF | 1192.9 [145.7 – 2240.1] |
180.2 [4.8 – 355.5] |
470.5 [0 – 1252.5] |
126.3 | 4.0 | |
| KatA | 679.2 [0 – 1657.9] |
121.4 [0 – 250.0] |
208.8 [0 – 575.1] |
54.2 | ND | |
| OprH | 44.1 [11.9 – 76.4] |
8.11 [1.6 – 14.6] |
22.6 [0 – 62.3] |
98.5 | ND | |
| IgM | WKC extract | 30.8 [23.5 – 38.1] |
27.7 [14.8 – 40.6] |
27.4 [25.5 – 29.2] |
22.2 | 23.8 |
| OprF | 31.1 [26.2 – 39.0] |
29.8 [12.7 – 46.8] |
29.1 [27.0 – 31.3] |
26.5 | 24.2 | |
| KatA | 28.9 [25.4 – 32.3] |
26.1 [12.6 – 39.7] |
27.0 [25.7 – 28.4] |
25.0 | 23.7 | |
| OprH | 25.5 [18.4 – 32.6] |
22.1 [18.6 – 25.5] |
23.8 [19.2 – 28.4] |
27.4 | 23.8 |
Values presented are the means and the 95% confidence intervals of the antibody concentrations (ng/ml). [a] Only one of the five samples was positive for Opr H; [b] BAL fluid samples within this group were pooled. CF, cystic fibrosis; LRT, lower respiratory tract; LRTI, lower respiratory tract infection; ND, No antibody was detected; URT, upper respiratory tract; WKC, whole killed cell.