Table 2. Serum antibody responses to P. aeruginosa antigens.
| Ig Isotype (µg/ml) | Antigen | Group 1 CF chronic LRTI(+) |
Group 2 CF LRTI (+) to (-) |
Group 3 CF URT (+) LRTI (-) |
Group 4 [b] CF URT (-) LRTI (-) |
Group 5 [b] Non-CF controls |
|---|---|---|---|---|---|---|
| IgG | WKC extract | 65.8 [0 - 277.0] |
20.3 [0 – 80.4] |
7.3 [0 – 27.3] |
4.2 | 4.7 |
| OprF | 64.1 [0 – 279.3] |
12.1 [0 - 37.3] |
9.8 [0 – 40.8] |
1.6 | 1.7 | |
| KatA | 54.5 [0 – 245.2] |
13.1 [32.8 – 59.0] |
7.1 [0 – 28.4] |
1.4 | 1.7 | |
| OprH | 20.5 [0 – 59.8] |
0.7 [0.2 – 1.3] |
2.4 [0 – 10.22] |
0.6 | 0.1 | |
| OprG | 13.6 [0 – 45.3] |
4.1 [0 – 13.8] |
3.4 [1.4 – 5.4] |
0.9 | 1.6 | |
| IgA | WKC extract | 28.4 [0 – 133.1] |
1.4 [0 – 5.2] |
20.6 [0 – 107.7] |
4.7 | 0.2 |
| OprF | 15.8 [0 – 81.7] |
1.2 [0 – 4.1] |
13.4 [0 – 70.4] |
2.1 | 0.2 | |
| KatA | 7.6 [0 – 38.6] |
0.5 [0 – 1.6] |
11.4 [0 – 58.1] |
2.3 | 0.1 | |
| OprH | 5.8 [0 – 24.6] |
0.2 [0 – 0.5] |
0.1 [a] |
0.3 | 0.1 | |
| OprG | 3.8 [0 – 15.8] |
0.4 [0 – 1.2] |
1.9 [0 – 1.3] |
0.3 | 0.2 | |
| IgM | WKC extract | 16.6 [0.5 – 32.7] |
1.6 [0 – 5.9] |
1.2 [0 – 4.0] |
2.5 | 0.1 |
| OprF | 15.8 [0 – 81.7] |
1.9 [0 – 6.8] |
3.7 [0 – 16.5] |
3.5 | 0.9 | |
| KatA | 6.3 [5.1 – 7.4] |
1.4 [0 – 5.0] |
2.1 [0 – 8.4] |
2.1 | 0.7 | |
| OprH | 2.8 [0 – 5.6] |
0.2 [0 – 0.5] |
0.4 [0 – 1.3] |
0.3 | 0.5 | |
| OprG | 3.3 [2.8 – 3.8] |
0.4 [0 – 1.2] |
1.6 [0 – 5.5] |
1.3 | 0.7 |
Values presented are the means and the 95% confidence intervals of the antibody concentrations (µg/ml). [a] Only one of the 5 samples was positive for Opr H; [b] Sera within this group were pooled for this group. CF, cystic fibrosis; LRT, lower respiratory tract; LRTI, lower respiratory tract infection; URT, upper respiratory tract; WKC, whole killed cell.