Table 3. Study participants.
Group | Clinical Status | Average Age (months) | Gender M:F |
---|---|---|---|
Group 1 CF chronic Pa LRTI n = 5 |
CF children with chronic Pa LRTI (≥ 105 CFU/mL) recovered in BAL samples ≥ 6 mths apart | 32.6 | 1:4 |
Group 2 CF URT (-) LRTI(+) to (-) n = 5 |
CF children with prior Pa LRTI (≥ 105 CFU/mL) and subsequent BAL culture negative42 | 30.2 | 0:5 |
Group 3 CF URT(+) LRTI (-) n = 5 |
CF children with URT colonisation (throat swab positive). BAL culture negative | 35.8 | 1:4 |
Group 4 CF controls URT(-) LRTI (-) n = 5 |
CF children without evidence of Pa LRTI or URT colonisation (BAL and throat swab culture negative) | 31.8 | 3:2 |
Group 5 Non-CF controls URT (-) LRTI (-) n = 6 |
Non-CF children undergoing flexible bronchoscopy to evaluate congenital stridor | 15.8 | 4:2 |
CFU, colony-forming units; CF, cystic fibrosis; LRTI, lower respiratory tract infection; Pa, Pseudomonas aeruginosa ; URT, upper respiratory tract.