Table 3. IL-2 production from PBL in the cynomolgus monkeys.
| (A) | (monkeys) Responder cell |
H37 Ra Ag | IL-2 (u/ml) |
|---|---|---|---|
| vaccine-treated | (-) | 2 ± 3 | |
| control | (-) | 0 ± 0 | |
| vaccine-treated | (+) | 13 ± 4 | |
| control | (+) | 3 ± 5 |
| (B) | G4 (saline control) |
IL-2 production (U/ml) (HSP65 stimulation) |
Survival | ||
|---|---|---|---|---|---|
| ID of monkeys | Baseline | Day53 Post-challenge |
|||
| PR 6847 D | 0.0 | 21.1 | Survival | ||
| PR 8018 B | 0.0 | 43.2 | Survival | ||
| PR 5368 B | 0.0 | 43.2 | Survival | ||
| PR PbB2–4F | 0.0 | 0.0 | Death (after 41 d) |
||
| PrZ7–51 AC | 0.0 | 0.0 | Death (after 55 d) |
||
(A)Augmentation of IL-2 production from PBL by H37Ra stimulation in the monkeys treated with HVJ-Envelope/HSP65 DNA + IL-12 DNA vaccine. (B) IL-2 production from PBL in the survived monkeys and the non-survived monkeys. PBL from monkeys on day 53 after TB challenge were stimulated with HSP65 protein for 3 d. ID (PR PbB2–4F) monkey and ID (PrZ7–51 AC) were died after 41 d and 55 d, respectively.