Table 1. Therapeutic efficacy of HVJ-Envelope/HSP65 DNA + IL-12 DNA vaccine on TB infection in murine models.

1. HVJ-Envelope/HSP65 DNA + IL-12 DNA vaccine showed therapeutic efficacy against MDR-TB as well as drug-sensitive TB in mice. 2. Significant prolongation of survival was observed in the XDR-TB infected mice by the treatment with this vaccine. 3. Therapeutic efficacy of this vaccine on chronic TB disease models using a mouse infected with TB in the aerosol chamber was demonstrated.

Therapeutic efficacy of HVJ-Envelope/HSP65 DNA + IL-12 DNA vaccine was evaluated by using mouse models. Therapeutic efficacies of this vaccine on the MDR-TB infection and XDR-TB infection were observed.