Table 3. In vivo anti-TB effect of 15kDa Granulysin Transgenic mouse.
mouse | lung Number of M. tuberculosis 4 weeks after TB injection (log) |
---|---|
G1 15K Granulysin Tg | 5.3 ± 0.35 |
G2 Wild Type C57BL/6 | 6.0 ± 0.5 |
Mean ± SD, n = 7; *p < 0.05 G1vsG2; Tukey-Kramer’s HSD; In vivo inhibition of the growth of M. Tuberculosis in the 15K granulysin transgenic mice; In vivo anti-TB effect of 15K granulysin transgenic mouse; Five 15 K granulysin transgenic mice and five wild type C57BL/6 mice were injected with 5 × 105 H37Rv M. tuberculosis i.v. Four weeks after the challenge of M. Tuberculosis, mice were sacrificed. CFU of M. Tuberculosis in the lungs of these mice were assessed described in Material and Methods. Student’s t-test was used (p < 0.05).