Figure 5. Cellular immune response against MV and the transgene, SIVgag. hCD46tg mice were given 0 or 500 mIU MV-nAb, one day prior to either i.m. or i.n. immunization with 1 × 105 pfu rMV-SIVgag. ELISPOTs were performed 2 weeks post immunization. Panels A and B represent the intramuscular (i.m.) immunization and the measurement of cellular immune response against MV-N (Panel A) and SIVgag (Panel B). Panels C and D represent the intranasal (i.n.) immunization and the measurement of cellular immune responses against MV-N (Panel C) and SIVgag (Panel D). The lines represent the median values.