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. 2013 Jan 7;9(3):712–719. doi: 10.4161/hv.23270

Table 1. General characteristics of cases included in the study and risk factors for IPD associated with PCV7 serotypes.

       All cases
     (n = 293),
     %		      PCV7 serotypes (n = 26), %      Non-PCV7 serotypes
     (n = 267),
     %		      OR (95% CI)      aOR (95% CI) a
     Sex-male      53.9      61.5      53.2      1.41 (0.62 – 3.22)      1.51 (0.59 – 3.84)  
     Age            
     3–23 mo      39.2      61.5      37.1      Reference      Reference  
     24–59 mo      60.8      38.5      62.9      0.37 (0.16 – 0.84)      0.50 (0.18 – 1.38)  
     Vaccination status            
     Non vaccinated      46.8      76.9      43.8      Reference      Reference  
     Vaccinated      45.4      19.2      47.9      0.23 (0.08 – 0.63)      0.15 (0.04 – 0.55)  
     Day care or school attendance      81.3      64.0      83.0      0.36 (0.15 – 0.88)      0.34 (0.13 – 0.89)  
     Antibiotic treatment      14.3      20.0      13.8      1.56 (0.55 – 4.43)      2.13 (0.66 – 6.82)  
     Respiratory infection      47.7      48.0      47.7      1.01 (0.44 – 2.30)      0.81 (0.30 – 2.22)  
     Breastfeeding      9.6      11.5      9.4      1.26 (0.35 – 4.50)      0.56 (0.13 – 2.40)  
     Exposure to tobacco in home            
     0 cigarettes/d      59.6      52.2      60.3      Reference      Reference  
     1–19 cigarettes/d      19.3      30.4      18.3      1.92 (0.72 – 5.16)      3.16 (0.96 – 10.43)  
     ≥ 20 cigarettes/d      21.1      17.4      21.4      0.94 (0.29 – 3.03)      1.10 (0.28 – 4.23)  
     Cohabitants > 4 persons      24.5      34.8      23.6      1.73 (0.70 – 4.28)      1.18 (0.43 – 3.25)  
     Siblings < 5 y      30.5      39.1      29.7      1.52 (0.63 – 3.66)      1.38 (0.54 – 3.53)  
     Social class            
     I-III      59.6      34.8      62.0      Reference      Reference  
     IV-V      40.4      65.2      38.0      3.06 (1.25 – 7.51)      2.03 (0.78 – 5.31)  
     Risk medical conditions      1.4      3.8      1.1      3.52 (0.35 – 35.11)      8.16 (0.65 – 102.43)  
     ICU      14.0      23.1      13.1      1.99 (0.75 – 5.29)      1.45 (0.46 – 4.58)  
     Death      1.0      3.8      0.7      5.30 (0.46 – 60.52)      1.67 (0.11 – 25.87)  
     Non-penicillin susceptibleb      34.8      70.6      28.6      2.45 (1.39 – 4.31)      2.01 (1.04 – 3.90)  

Notes: aAdjusted for age, vaccination with ≥ 1 dose of PCV7, attending day care or school, antibiotics prescribed within 30 d before the onset of clinical symptoms and previous respiratory infection. bAntibiogram was performed in cases diagnosed by culture (n = 115). Abbreviations: y, year; m, months; d, days; OR, odds ratio; aOR, adjusted odds ratio; PCV7, 7-valent pneumococcal conjugate vaccine; ICU, intensive care unit; IPD, invasive pneumococcal disease.