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. 2014 Jan 14;9(1):e85144. doi: 10.1371/journal.pone.0085144

Figure 11. The CSD peptide attenuated TGF-β1-induced downregulation of MMPs in HAFs.

Figure 11

HAFs were pretreated with the CSD peptide (5 µM) or the Scr peptide (5 µM) for 30 min, and subsequently incubated with or without 100 ng/ml TGF-β1 for 48 h. Note that the CSD peptide remarkably reversed the TGF-β1-induced downregulation of MMP-1, MMP-2 and MMP-9. MMP, matrix metalloproteinase. HAFs, human atrial fibroblasts. The CSD peptide, peptides derived from the scaffolding domain of caveolin-1; Scr peptide, scrambled peptide. *P<0.05 vs. Control; #P<0.05 vs. TGF-β1. n = 3 per group with each measurement conducted in triplicate.