Figure 7. Sublethal irradiation and anti-PD-L1 is also effective in the treatment of other hematologic malignancies.

A. PD-L1 expression on cultured 5T33, B16F10, AGN2a, A20, EL4, and C1498 cells is depicted in flow cytometry histograms. Solid curves represent isotype controls. B. Survival curves are shown for mice inoculated with the indicated tumors. The experimental design followed that depicted in Figure 2A. Briefly, approximately one week after inoculation mice received 0 or 500 cGy irradiation and then were treated on six days with anti-PD-L1 or control IgG. Survival curves are from 1-3 independent experiments; n=8-20 mice per experimental group.