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. 2014 Jan 14;9(1):e85336. doi: 10.1371/journal.pone.0085336

Table 1. Incidence of tumor formation after transplanting HeLa cells in various immunodeficient mice.

strain use of Matrigel min.dose fortumor formation weeks to observeTumor (first to last) number of mice Log10TPD50
nude with 1×104 cells 3 to 8 120 3.5
nude w/o 1×104 cells 4 to 12 120 4.9
SCID with 1×103 cells 3 to 11 24 2.5
SCID w/o 1×103 cells 3 to 11 24 3.83
NOD-SCID with 1×102 cells 3 to 16 24 2.17
NOD-SCID w/o 1×103 cells 3 to 14 24 3.5
NOG with 1×101 cells 5 to 18 75 1.1
NOG w/o 1×104 cells 3 to 13 105 3.97

Log10TPD50 values for HeLa cells transplanted subcutaneously into various immunodeficient mouse strains with or without Matrigel. Tumor-forming potentials of HeLa cells in nude mice without Matrigel and in NOG mice with Matrigel are highlighted in gray.