Figure 3.
PPARγ agonism normalizes Pr but not the size of the RRP in 9MO Tg2576 DG. A, Representative traces recorded from dentate granule cell evoked responses to mPP high-frequency stimulation (20 Hz, 1.6 s). B, eEPSC cumulative charge transfer did not differ among groups. C, The RRP did not differ among groups (F(2,23) = 1.8, p = 0.18, one-way ANOVA with Dunnett's post hoc comparison). D, The Pr was higher in Tg2576 compared with WT, which did not differ from Tg2576 treated with RSG (p > 0.05, one-way ANOVA with Dunnett's post hoc comparison). Results are mean ± SEM; n = 11 (WT), 7 (Tg2576), and 8 (Tg2576 + RSG). Calibration: 25 pA, 250 ms; *p < 0.05, **p < 0.01, ***p < 0.001.