Figure 4.

DG network of SNARE-regulatory proteins modulated by RSG treatment of Tg2576. Proteins identified via quantitative MS were subjected to IPA to reveal the extensive inter-relationships between the indicated proteins. The highest scoring network is shown (score = 64). Green, induced by RSG; white, no change; STXBP5, syntaxin-binding protein 5; NSF, vesicle-fusing ATPase; PCLO, protein piccolo; RIMS1 and RIMS2, regulating synaptic membrane exocytosis proteins 1 and 2; SNAP-25, synaptosomal-associated protein 25; STX1A, syntaxin-1A; SYT1, synatpotagmin-1; VAPA and VAPB, vesicle-associated membrane protein-associated proteins A and B.