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. 2014 Jan 15;34(3):1057–1066. doi: 10.1523/JNEUROSCI.4336-13.2014

Figure 4.

Figure 4.

KC-2-009, an inverse agonist of the μ-opioid receptor, potentiated GABA release in cocaine-extinguished rats but not in yoked saline rats. A, 1 μm KC-2-009 increased the amplitude of GABA eIPSCs after extinction of cocaine self-administration (two-way ANOVA; F(1,26) = 4.59, p < 0.05 for main effect of group; F(1,26) = 7.48, p < 0.05 for interaction group × treatment). Number of cells presented above number of rats (in parentheses). B, KC-2-009 altered the PPR only in cocaine-extinguished rats (two-way ANOVA; F(1,18) = 4.43, p < 0.05 for main effect of group; F(1,18) = 4.51, p < 0.05 for interaction group × treatment). *p < 0.05 comparing the two groups at 1 μm KC-2-009 using two-way ANOVA and Bonferroni post hoc analysis. Data presented as mean ± SEM.