Table 1.
Geometric mean and percent control of on-animal flea counts in naturally infested homes when dogs and cats were treated with indoxacarb or fipronil (s)-methoprene based topical spot-on formulations
|
Treatment group |
# dogs/cats |
|
Days post-treatment
1
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Day 0 | Day 7 | Day 14 | Day 21 | Day 28 – 30 | Day 40 - 45 | Day 54 - 60 | |||
| Indoxacarb2 |
32/3 |
Geomean4 |
51.0a |
1.1a |
0.6a |
1.3a |
2.6a |
0.3a |
0.5a |
| |
% control5 |
|
97.8 |
98.8 |
97.4 |
95.0 |
99.4 |
99.1 |
|
| |
% (#) pets with no fleas |
0.0 |
48.6 |
71.4 |
40.0 |
20.0 |
71.4 |
77.1 |
|
| (0/35) |
(17/35) |
(25/35) |
(14/35) |
(7/35) |
(25/35) |
(27/35) |
|||
| Fipronil (s)-methoprene3 |
30/2 |
Geomean |
28.1a |
4.1b |
6.4b |
13.6b |
14.2b |
8.0b |
12.7b |
| |
% control |
|
85.5 |
77.3 |
51.5 |
49.5 |
71.6 |
54.8 |
|
| |
% (#) pets with no fleas |
0.0 |
15.6 |
15.6 |
9.4 |
6.3 |
21.9 |
15.6 |
|
| (0/32) | (5/32) | (5/32) | (3/32) | (2/32) | (7/32) | (5/32) | |||
1Dogs and cats treated on day 0 and again between days 28 – 30.
2Dogs and cats were treated topically with indoxacarb (19.53% w/w; ACTIVYL® Merck Animal Health) according to label directions.
3Dogs were treated topically with fipronil (9.8% w/w)–(s)-methoprene (8.8% w/w) spot-on (Frontline®Plus; Merial) and cats were treated topically with fipronil (9.8% w/w)–(s)-methoprene (11.8% w/w) (Frontline®Plus; Merial) according to label directions.
4Geometric mean numbers of fleas in visual area counts on pets.
5{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts)/day 0 geometric mean animal area flea counts)} x 100
a,bGeometric means in a column with unlike letter superscripts are significantly different (P values ≤0.0079).