Table 1.

Summary of assays performed

Test	Vial	Apparatus	Place of analysis	Normal range
ROTEM® using the following reagents: EXTEM, FIBTEM®, INTEM, APTEM, NATEM, HEPTEM®, recording the following results: CT (Clotting time), CFT (Clot formation time), Alpha-Angle (AA), MCF (Maximum Clot Firmness), ML (Maximum Lysis).	2.7mL citrate tubes for ROTEM® analysis (3.2% citrate, BD Vacutainer® Systems, Plymouth, UK)	ROTEM®, Pentapharm, Munich, Germany	Point-of-care laboratory, Intensive Care Unit	See Table 2.
Multiplate® using the following agonists: adenosine diphosphate, collagen, thrombin receptor activator, recording the following results for each agonist: area under curve (AUC), aggregation (AU), velocity (AU/min).	3.0mL Hirudin tubes. Dynabyte GmbH, Munich, Germany.	Multiplate®, Roche, Basel, Switzerland		See Table 2.
aPTT: activated partial thromboplastin time	2.7mL citrate tubes (3.2% citrate, BD Vacutainer® Systems, Plymouth, UK)	PTT-Automate, Stago (Asnière sur Seine, France)	Hospital’s usual clinical chemistry laboratory	28 to 45 seconds at the time of the study
PT-INR: prothrombin time-international normalized ratio		Stago prothrombin complex assay, Stago calibrated by Equalis, (Uppsala, Sweden)		≤1.2
Plc: platelet count	3.0mL K2EDTA tubes (BD Vacutainer® Systems, Plymouth UK)	Sysmex XE 5000 cell counter, Sysmex Corp., (Kobe, Japan).		165 to 387 million/mL and 145 to 387 million/mL for women and men respectively