Table 5.
Analysis of baseline-adjusted AUC from 6 to 24 hours for all outcome measures
| |
|
Placebo |
IL-1Ra |
|
|
||
|---|---|---|---|---|---|---|---|
| Mediator | Location | Raw | Adjusted | Raw | Adjusted | Difference | P value |
| IL-6 |
CSF |
107.3 |
0.2 |
111.0 |
−12.6 |
12.8 (−2.1 to 27.7) |
0.08 |
| |
Plasma |
37.7 |
−3.7 |
49.7 |
−22.3 |
18.6 (−0.6 to 37.7) |
0.06 |
| IL-8 |
CSF |
114.8 |
4.8 |
104.7 |
−2.3 |
7.1 (−5.4 to 19.5) |
0.23 |
| |
Plasma |
37.8 |
6.4 |
39.8 |
−0.3 |
6.7 (−4.9 to 18.3) |
0.23 |
| IL-10 |
CSF |
14.6 |
−6.3 |
25.0 |
−8.1 |
1.8 (−8.6 to 12.2) |
0.70 |
| |
Plasma |
6.7 |
0.5 |
9.1 |
−17.1 |
17.6 (4.3 to 30.9) |
0.01 |
| MCP-1 |
CSF |
139.8 |
1.5 |
145.4 |
−4.0 |
5.5 (−3.9 to 15.0) |
0.22 |
| |
Plasma |
68.7 |
−4.3 |
79.2 |
−4.0 |
−0.3 (−14.0 to 13.3) |
0.96 |
| CRP | Plasma | 65.2 | −1.6 | 84.5 | −0.5 | −1.1 (−10.3 to 8.1) | 0.79 |
Figures are the mean AUC for the natural logarithm of each marker plotted against time from 6 to 24 hours. Both ‘raw’ (actual values) and baseline-adjusted (subtracting the rectangular area defined by the height of the baseline reading across the 18-hour period) are presented. The mean difference (95% CI) and associated P value are given for the adjusted values. AUC, area under the curve; CRP, C-reactive protein; CSF, cerebrospinal fluid; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist; MCP-1, monocyte chemoattractant protein-1.