Table 1.
Mean 14C-content ± SD and calculated adduct levels ± SD of DNA isolated from kidney and liver of [3,4-14C]-furan treated and control rats.
Tissue | Dose Group [mg/kg bw] | 14C-Content [amol/μg DNA] | Adduct Level [Adducts/109 Nucleotides] |
---|---|---|---|
0 | 0.2 ± 0.2 | 0 | |
Kidney | 0.1 | 2.6 ± 0.3 | 5.1 ± 0.6 |
2.0 | 60.2 ± 25.3 | 127.2 ± 53.6 | |
0 | 0.1 ± 0.1 | 0 | |
Liver left lobe | 0.1 | 6.4 ± 1.2 | 13.3 ± 2.5 |
2.0 | 208.1 ± 112.7 | 441.5 ± 239.2 | |
0 | 0.1 ± 0.1 | 0 | |
Liver caudate lobe | 0.1 | 9.4 ± 4.5 | 19.7 ± 9.6 |
2.0 | 98.6 ± 48.9 | 208.9 ± 103.8 | |
0 | 0.1 ± 0.1 | 0 | |
Liver (mean) | 0.1 | 7.9 ± 3.5 | 16.5 ± 7.4 |
2.0 | 153.3 ± 100.2 | 325.2 ± 212.7 |