Fig. 2. Site-specific insertions of UAS-2N4R Tau mediate lower levels of toxicity.

UAS-2N4R Tau was inserted into five specific genomic landing sites by φC31-mediated integration. (A) Light micrographs of adult eyes from GMR-gal4 × wild-type (control) or UAS-2N4R Tau crosses. Areas of the eye displaying significant disruption are highlighted with dashed lines. (B) Tau transcript levels driven by GMR-gal4 from two site-specific UAS insertions normalised to our random insertion line 3.