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. 2013 Aug 22;280(21):5269–5282. doi: 10.1111/febs.12453

Figure 3.

Figure 3

Loss of STAT3 results in reduced MYCN levels. Two independent STAT3 siRNAs (#1 or #2) were employed to downregulate STAT3 levels in CLB-GE (A), CLB-BAR (B), Kelly (C) and CLB-GA (D) neuroblastoma cell lines. Cells were transfected with either control scrambled siRNA, STAT3 siRNA#1 or STAT3 siRNA#2 prior to cell lysis 48 h post-transfection. Whole cell lysates were subsequently immunoblotted for STAT3, MYCN, and pan-ERK (as loading control), as indicated. Lfm, lipofectamine; scC, scramble control.